2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-143941S
    Hydroxychloroquine EP impurity D-d5 dihydrochloride
    Hydroxychloroquine EP impurity D-d5 (dihydrochloride) is the deuterium labeled Hydroxychloroquine EP impurity D dihydrochloride[1].
    Hydroxychloroquine EP impurity D-d<sub>5</sub> dihydrochloride
  • HY-116016
    Etilevodopa
    		99.00%
    Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine.
    Etilevodopa
  • HY-114750
    Mebendazole-amine
    Mebendazole-amine is a metabolite of Mebendazole. Mebendazole is a broad-spectrum benzimidazole anti-helminthic agent.
    Mebendazole-amine
  • HY-136124
    Cetilistat impurity 1
    Cetilistat impurity 1 is an impurity of Cetilistat. Cetilistat, an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively.
    Cetilistat impurity 1
  • HY-115420
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E)) is a glucosylsphingosine, which are deacetylated lysolipid derivatives of glucosylcerebrosides.
    1-β-D-Glucosylsphingadienine (d18:2 (4E8E))
  • HY-137532
    7-Hydroxyquetiapine
    7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].
    7-Hydroxyquetiapine
  • HY-124030
    3-Hydroxyphenazepam
    3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [3H]GABA uptake.
    3-Hydroxyphenazepam
  • HY-131253
    Febuxostat isopropyl isomer
    Febuxostat isopropyl isomer is an impurity of Febuxostat. Febuxostat is selective xanthine oxidase inhibitor with a Ki of 0.6 nM.
    Febuxostat isopropyl isomer
  • HY-Z1430S
    (3R,4S)-Paroxetine-d4 hydrochloride
    Paroxetine EP impurity D-d4 (hydrochloride) is deuterium labeled (3R,4S)-3-((benzo[d][1,3]dioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine  (Paroxetine Impurity）.
    (3R,4S)-Paroxetine-d<sub>4</sub> hydrochloride
  • HY-N12843
    2-Deoxokanshone M
    2-Deoxokanshone M (Nardosinone acid) is a degradation product of Nardosinone (HY-N0380) and has potent vasodilatory activity.
    2-Deoxokanshone M
  • HY-117934
    Isokotanin B
    Isokotanin B is a metabolite of bicoumarin isolated from the sclerotia of Aspergillus alliaceus. Isokotanin B shows activity against the corn earworm Helicoverpa zea and the dried fruit bettle Carpophilus hemipterus.
    Isokotanin B
  • HY-136345
    (Rac)-3′-Hydroxy simvastatin
    (Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM.
    (Rac)-3′-Hydroxy simvastatin
  • HY-W012982R
    3-Amino-2-oxazolidinone (Standard)
    3-Amino-2-oxazolidinone (Standard) is the analytical standard of 3-Amino-2-oxazolidinone. This product is intended for research and analytical applications. 3-Amino-2-oxazolidinone (AOZ) is the metabolite of Furazolidone (HY-B1336). 3-Amino-2-oxazolidinone is always be detected as a indicator of furazolidone residues in vivo.
    3-Amino-2-oxazolidinone (Standard)
  • HY-131629
    N-Desmethyl-U-47700
    N-Desmethyl-U-47700 is the primary metabolite of U-47700 (an opioid agonist).
    N-Desmethyl-U-47700
  • HY-W777199
    Tianeptine metabolite MC5 sodium salt
    Tianeptine metabolite MC5 sodium salt is a major active metabolite of tianeptine. Tianeptine and MC5 metabolite are eliminated with bile as glucuronide and glutamine conjugates.
    Tianeptine metabolite MC5 sodium salt
  • HY-145480
    Silodosin Glucuronide sodium
    Silodosin Glucuronide sodium (Silodosin β-D-glucuronide sodium) is the metabolite of Silodosin (HY-10122). Silodosin is a selective and orally active antagonist for α1A-adrenergic receptor (α1A-AR) with Ki of 0.036 nM.
    Silodosin Glucuronide sodium
  • HY-108251R
    Methotrexate metabolite (Standard)
    Methotrexate metabolite (Standard) is the analytical standard of Methotrexate metabolite. This product is intended for research and analytical applications. Methotrexate metabolite (DAMPA), the active metabolite of Methotrexate. Methotrexate is a folic acid antagonist that is widely used as an immunosuppressant and chemotherapeutic agent.
    Methotrexate metabolite (Standard)
  • HY-101108S1
    Tazarotenic acid-13C2,d2
    Tazarotenic acid-13C2,d2 (AGN 190299-13C2,d2) is the 13C and deuterium labeled isotope of Tazarotenic acid (HY-101108). Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma.
    Tazarotenic acid-<sup>13</sup>C<sub>2</sub>,d<sub>2</sub>
  • HY-130239
    14(S)-HDHA
    14(S)-HDHA (14(S)-HDoHE) is an oxygenation product of Docosahexaenoic acid (DHA). 14(S)-HDHA is a marker reflecting activation of a Docosahexaenoic acid carbon 14-lipoxygenation pathway.
    14(S)-HDHA
  • HY-131257
    Gefitinib impurity 1
    		99.59%
    Gefitinib impurity 1 is the impurity of Gefitinib. Gefitinib (ZD1839) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib also induces autophagy. Gefitinib has antitumour activity.
    Gefitinib impurity 1
Cat. No. Product Name / Synonyms Application Reactivity